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DDX3 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71312

  • Amount:

    100ul

  • Reactivity:

    Human,Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen..

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human DDX3. AA range:14-63

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of Jurkat cells using DDX3 Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    DDX3X/DDX3Y

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    ATP-dependent RNA helicase DDX3X/Y

  • Human Gene Id:

    1654/8653

  • Human Swiss Prot No:

    O00571/O15523

  • Specificity:

    DDX3 Polyclonal Antibody detects endogenous levels of DDX3 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DDX3X; DBX; DDX3; ATP-dependent RNA helicase DDX3X; DEAD box protein 3; X-chromosomal; DEAD box, X isoform; Helicase-like protein 2; HLP2; DDX3Y; DBY; ATP-dependent RNA helicase DDX3Y; DEAD box protein 3, Y-chromosomalMolecularWeight: 73243/73154Da

  • Observed Band(KD):

    73

  • Background:

    DEAD-box helicase 3, X-linked(DDX3X) Homo sapiens The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarit

  • Function:

    function:ATP-dependent RNA helicase. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. Also involved in HIV-1 replication. Interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location.,similarity:Belongs to the DEAD box helicase family.,similarity:Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subcellular location:Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1-dependent manner.,subunit:Found in a complex with Rev and XPO1. Interacts with XPO1 and TDRD3. Interacts with HCV core protein.,

  • Subcellular Location:

    nucleus,cytoplasm,mitochondrial outer membrane,eukaryotic translation initiation factor 3 complex,cell-cell adherens junction,cytoplasmic stress granule,nuclear speck,cytosolic small ribosomal subunit,extracellular exosome,

  • Western Blot analysis of L929 MCF7 HELA cells using Antibody diluted at 1:2000. Secondary antibody was diluted at 1:20000.

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Catalog Number

  • Amount:100ul
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DDX3 Polyclonal Antibody | EnoGene Biotech Co. Ltd