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DBH Polyclonal Antibody
Datasheet
Catalog Number:
E20-71296Amount:
100ulReactivity:
Human,Mouse,RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen..Immunogen:
The antiserum was produced against synthesized peptide derived from human DBH. AA range:401-450Source:
Polyclonal, Rabbit
- .
Western Blot analysis of Jurkat cells using DBH Polyclonal Antibody Gene Name:
DBHDilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
Dopamine beta-hydroxylaseHuman Gene Id:
1621Human Swiss Prot No:
P09172Specificity:
DBH Polyclonal Antibody detects endogenous levels of DBH protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
DBH; Dopamine beta-hydroxylase; Dopamine beta-monooxygenaseMolecularWeight: 69065DaObserved Band(KD):
69Background:
dopamine beta-hydroxylase(DBH) Homo sapiens The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008],Function:
catalytic activity:3,4-dihydroxyphenethylamine + ascorbate + O(2) = noradrenaline + dehydroascorbate + H(2)O.,cofactor:Binds 1 PQQ per subunit.,cofactor:Binds 2 copper ions per subunit.,disease:Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.,function:Conversion of dopamine to noradrenaline.,induction:Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids.,online information:Dopamine beta hydroxylase entry,pathway:Catecholamine biosynthesis; norepinephrine biosynthesis; norepinephrine from dopamine: step 1/1.,polymorphism.Subcellular Location:
extracellular region,extracellular space,cytoplasm,membrane,integral component of membrane,transport vesicle membrane,secretory granule membrane,chromaffin granule lumen,secretory granule lumen,chromaffin granule membrane,
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