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D4DR Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71278

  • Amount:

    100ul

  • Molecular Weight:

    48361Da

  • Applications:

    WB;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human DRD4. AA range:355-404

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using D4DR Polyclonal Antibody

  • Gene Name:

    DRD4

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    D(4) dopamine receptor

  • Human Gene Id:

    1815

  • Human Swiss Prot No:

    P21917

  • Mouse Gene Id:

    13491

  • Mouse Swiss Prot No:

    P51436

  • Rat Gene Id:

    25432

  • Rat Swiss Prot No:

    P30729

  • Specificity:

    D4DR Polyclonal Antibody detects endogenous levels of D4DR protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DRD4; D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor

  • Observed Band(KD):

    48

  • Background:

    This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008],

  • Function:

    function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:The number of repeats of 16 amino acids in the third cytoplasmic loop is highly polymorphic and varies among different alleles. Alleles corresponding in size to a 2 (D4.2), 3 (D4.3), 4 (D4.4), 5 (D4.5), 6 (D4.6), 7 (D4.7) and 9 (D4.9) repeats have been described. The sequence shown is that of allele D4.7. The polymorphic repeat sequence has little influence on DRD4-binding profiles and might not be essential for G protein interaction.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CLIC6 (By similarity) and GPRASP1.,

  • Subcellular Location:

    Cell membrane ; Multi-pass membrane protein .

  • Expression:

    Highly expressed in retina. Detected at much lower levels in brain, in amygdala, thalamus, hypothalamus, cerebellum and pituitary.

  • Western Blot analysis of K562 cells using D4DR Polyclonal Antibody

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Catalog Number

  • Amount:100ul
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D4DR Polyclonal Antibody | EnoGene Biotech Co. Ltd