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Cell Signal Transduction Research Antibodies
CysLTR1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight38541Da
Protein NameCysteinyl leukotriene receptor 1
Human Gene Id10800
Human Swiss Prot NoQ9Y271
Mouse Swiss Prot NoQ99JA4
SpecificityCysLTR1 Polyclonal Antibody detects endogenous levels of CysLTR1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCYSLTR1; CYSLT1; Cysteinyl leukotriene receptor 1; CysLTR1; Cysteinyl leukotriene D4 receptor; LTD4 receptor; G-protein coupled receptor HG55; HMTMF81
Observed Band(KD)38
Functionfunction:Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.,miscellaneous:Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages),
Subcellular Locationplasma membrane,integral component of plasma membrane,membrane,
ExpressionLeukocyte,Pancreas,Peripheral blood monocyte,Spleen,Tonsil,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human CYSLTR1. AA range:131-180
Gene NameCYSLTR1
DilutionWestern Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Backgroundcysteinyl leukotriene receptor 1(CYSLTR1) Homo sapiens This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
Conjugated Antibody
This product is also available conjugated. Format: E20-71244-Conjugate. Price: $485 / Size: 100μl.
E20-71244-FITC$485 / 100μlE20-71244-Biotin$485 / 100μlE20-71244-HRP$485 / 100μlE20-71244-AP$485 / 100μlE20-71244-AF350$485 / 100μlE20-71244-AF405M$485 / 100μlE20-71244-AF488$485 / 100μlE20-71244-AF514$485 / 100μlE20-71244-AF532$485 / 100μlE20-71244-AF555$485 / 100μlE20-71244-AF568$485 / 100μlE20-71244-AF405S$485 / 100μlE20-71244-AF405L$485 / 100μlE20-71244-AF546$485 / 100μlE20-71244-AF594$485 / 100μlE20-71244-AF610$485 / 100μlE20-71244-AF635$485 / 100μlE20-71244-AF647$485 / 100μlE20-71244-AF680$485 / 100μlE20-71244-AF700$485 / 100μlE20-71244-AF750$485 / 100μlE20-71244-AF790$485 / 100μlE20-71244-APC$485 / 100μlE20-71244-PE$485 / 100μlE20-71244-Cy3$485 / 100μlE20-71244-Cy5$485 / 100μlE20-71244-Cy5.5$485 / 100μlE20-71244-Cy7$485 / 100μlE20-71244-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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