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CYP4B1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71233Amount:
100ulMolecular Weight:
58991DaReactivity:
Human,Mouse,RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 4B1. AA range:141-190Source:
Polyclonal, Rabbit
- Western Blot analysis of COLO cells using CYP4B1 Polyclonal Antibody
Gene Name:
CYP4B1Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.Background:
cytochrome P450 family 4 subfamily B member 1(CYP4B1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016],Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Protein Name:
Cytochrome P450 4B1Human Gene Id:
1580Human Swiss Prot No:
P13584Specificity:
CYP4B1 Polyclonal Antibody detects endogenous levels of CYP4B1 protein.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CYP4B1; Cytochrome P450 4B1; CYPIVB1; Cytochrome P450-HPObserved Band(KD):
50Function:
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.,induction:P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.,online information:CYP4B1 alleles,similarity:Belongs to the cytochrome P450 family.,Subcellular Location:
endoplasmic reticulum membrane,integral component of membrane,organelle membrane,
- Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Cytochrome P450 4B1 Antibody. The picture on the right is blocked with the synthesized peptide.
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