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CYP39A1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71226Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 39A1. AA range:361-410Source:
Polyclonal, RabbitGene Name:
CYP39A1Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
- Western blot analysis of lysates from LOVO and HUVEC cells, using Cytochrome P450 39A1 Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
cytochrome P450 family 39 subfamily A member 1(CYP39A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],Protein Name:
24-hydroxycholesterol 7-alpha-hydroxylaseHuman Gene Id:
51302Human Swiss Prot No:
Q9NYL5Mouse Gene Id:
56050Mouse Swiss Prot No:
Q9JKJ9Specificity:
CYP39A1 Polyclonal Antibody detects endogenous levels of CYP39A1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CYP39A1; 24-hydroxycholesterol 7-alpha-hydroxylase; Cytochrome P450 39A1; hCYP39A1; Oxysterol 7-alpha-hydroxylaseMolecularWeight(Da):
54116Observed Band(KD):
54Function:
catalytic activity:(24R)-cholest-5-ene-3-beta,24-diol + NADPH + O(2) = (24R)-cholest-5-ene-3-beta,7-alpha,24-triol + NADP(+) + H(2)O.,cofactor:Heme group.,function:Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Liver specific.,Subcellular Location:
endoplasmic reticulum membrane,integral component of membrane,organelle membrane,intracellular membrane-bounded organelle,Expression:
Liver,Skin,
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Catalog Number
- Amount:100ul
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