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CYP2S1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71223Amount:
100ulMolecular Weight:
55817 DaObserved Band:56 KDApplications:
WB;IHC-p;IF/ICC;ELISAReactivity:
Human;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2S1. AA range:181-230Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using CYP2S1 Polyclonal Antibody diluted at 1:2000
Gene Name:
CYP2S1Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.Protein Name:
Cytochrome P450 2S1Human Gene Id:
29785Human Swiss Prot No:
Q96SQ9Mouse Gene Id:
74134Mouse Swiss Prot No:
Q9DBX6Specificity:
CYP2S1 Polyclonal Antibody detects endogenous levels of CYP2S1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CYP2S1; Cytochrome P450 2S1; CYPIIS1Background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008],Function:
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Has a potential importance for extrahepatic xenobiotic metabolism.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:High level of expression in trachea, lung, stomach, small intestine, and spleen.,Subcellular Location:
Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .Expression:
Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen (PubMed:11181079, PubMed:12711469). Expressed in peripheral blood leukocytes (PubMed:11181079). Constitutively expressed in skin (at protein level) (PubMed:12711469).
- Immunofluorescence analysis of A549 cells, using Cytochrome P450 2S1 Antibody. The picture on the right is blocked with the synthesized peptide.
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