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Cell Signal Transduction Research Antibodies
CYP2R1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight57359DaObserved Band:52KD
Protein NameVitamin D 25-hydroxylase
Human Gene Id120227
Human Swiss Prot NoQ6VVX0
Mouse Gene Id244209
Mouse Swiss Prot NoQ6VVW9
SpecificityCYP2R1 Polyclonal Antibody detects endogenous levels of CYP2R1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCYP2R1; Vitamin D 25-hydroxylase; Cytochrome P450 2R1
Functioncatalytic activity:5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O(2) = (25R)-5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP(+) + H(2)O.,cofactor:Heme group.,disease:Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency (25HOD3D)[MIM:600081]; also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity, and low levels of 25-hydroxyvitamin D.,function:Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).,similarity:Belongs to the cytochrome P450 family.,subunit:Homodimer.,
Subcellular Locationendoplasmic reticulum membrane,organelle membrane,
ExpressionLiver,,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human CYP2R1. AA range:251-300
Gene NameCYP2R1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications
Backgroundcytochrome P450 family 2 subfamily R member 1(CYP2R1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-71222-Conjugate. Price: $485 / Size: 100μl.
E20-71222-FITC$485 / 100μlE20-71222-Biotin$485 / 100μlE20-71222-HRP$485 / 100μlE20-71222-AP$485 / 100μlE20-71222-AF350$485 / 100μlE20-71222-AF405M$485 / 100μlE20-71222-AF488$485 / 100μlE20-71222-AF514$485 / 100μlE20-71222-AF532$485 / 100μlE20-71222-AF555$485 / 100μlE20-71222-AF568$485 / 100μlE20-71222-AF405S$485 / 100μlE20-71222-AF405L$485 / 100μlE20-71222-AF546$485 / 100μlE20-71222-AF594$485 / 100μlE20-71222-AF610$485 / 100μlE20-71222-AF635$485 / 100μlE20-71222-AF647$485 / 100μlE20-71222-AF680$485 / 100μlE20-71222-AF700$485 / 100μlE20-71222-AF750$485 / 100μlE20-71222-AF790$485 / 100μlE20-71222-APC$485 / 100μlE20-71222-PE$485 / 100μlE20-71222-Cy3$485 / 100μlE20-71222-Cy5$485 / 100μlE20-71222-Cy5.5$485 / 100μlE20-71222-Cy7$485 / 100μlE20-71222-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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