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CYP2E1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71220

  • Amount:

    100ul

  • Molecular Weight:

    56849Da

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2E1. AA range:371-420

  • Source:

    Polyclonal, Rabbit

  • Immunofluorescence analysis of Hela cell. 1,CYP2E1 Polyclonal Antibody(green) was diluted at 1:200(4° overnight). 2, Goat Anti Rabbit Alexa Fluor 488Catalog:RS3211 was diluted at 1:1000(room temperature, 50min). 3 DAPI(blue) 10min

  • Gene Name:

    CYP2E1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications

  • Protein Name:

    Cytochrome P450 2E1

  • Human Gene Id:

    1571

  • Human Swiss Prot No:

    P05181

  • Specificity:

    CYP2E1 Polyclonal Antibody detects endogenous levels of CYP2E1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CYP2E1; CYP2E; Cytochrome P450 2E1; 4-nitrophenol 2-hydroxylase; CYPIIE1; Cytochrome P450-J

  • Observed Band(KD):

    56

  • Background:

    cytochrome P450 family 2 subfamily E member 1(CYP2E1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]

  • Function:

    catalytic activity:4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.,cofactor:Heme group.,function:Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.,induction:By ethanol and isoniazid.,online information:CYP2E1 alleles,online information:CYP2E1 entry,similarity:Belongs to the cytochrome P450 family

  • Subcellular Location:

    Golgi membrane,mitochondrion,endoplasmic reticulum membrane,intrinsic component of endoplasmic reticulum membrane

  • Western Blot analysis of KB cells using CYP2E1 Polyclonal Antibody diluted at 1:500

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Catalog Number

  • Amount:100ul
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CYP2E1 Polyclonal Antibody | EnoGene Biotech Co. Ltd