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CUG-BP1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71156

  • Amount:

    100ul

  • Molecular Weight:

    52063 DaObserved Band:52 KD

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CELF-1. AA range:71-120

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using CUG-BP1 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    CELF1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    CUGBP Elav-like family member 1

  • Human Gene Id:

    10658

  • Human Swiss Prot No:

    Q92879

  • Mouse Gene Id:

    13046

  • Mouse Swiss Prot No:

    P28659

  • Rat Gene Id:

    362160

  • Rat Swiss Prot No:

    Q4QQT3

  • Specificity:

    CUG-BP1 Polyclonal Antibody detects endogenous levels of CUG-BP1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CELF1; BRUNOL2; CUGBP; CUGBP1; NAB50; CUGBP Elav-like family member 1; CELF-1; 50 kDa nuclear polyadenylated RNA-binding protein; Bruno-like protein 2; CUG triplet repeat RNA-binding protein 1; CUG-BP1; CUG-BP- and ETR-3-like factor 1; Dead

  • Background:

    CUGBP, Elav-like family member 1(CELF1) Homo sapiens Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

  • Function:

    disease:CUGBP1 may be involved in the mechanism of myotonic distrophy. It binds to the CUG repeat expansion of the CC untranslated region of the myotonin protein kinase (Mt-PK) gene.,function:RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes ex

  • Subcellular Location:

    Nucleus . Cytoplasm . RNA-binding activity is detected in both nuclear and cytoplasmic compartments.

  • Expression:

    Ubiquitous.

  • Western blot analysis of lysates from HeLa and HepG2 cells, using CELF-1 Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

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CUG-BP1 Polyclonal Antibody | EnoGene Biotech Co. Ltd