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CTPS Polyclonal Antibody
Datasheet
Catalog Number:
E20-71153Amount:
100ulMolecular Weight:
66690 DaObserved Band:67 KDApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CTPS. AA range:60-109Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using CTPS Polyclonal Antibody diluted at 1:500
Gene Name:
CTPS1Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.Protein Name:
CTP synthase 1Human Gene Id:
1503Human Swiss Prot No:
P17812Mouse Gene Id:
51797Mouse Swiss Prot No:
P70698Specificity:
CTPS Polyclonal Antibody detects endogenous levels of CTPS protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CTPS1; CTPS; CTP synthase 1; CTP synthetase 1; UTP--ammonia ligase 1Background:
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],Function:
catalytic activity:ATP + UTP + NH(3) = ADP + phosphate + CTP.,enzyme regulation:Activated by GTP and inhibited by CTP.,function:Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.,pathway:Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.,similarity:Belongs to the CTP synthase family.,similarity:Contains 1 glutamine amidotransferase type-1 domain.,Subcellular Location:
Cytoplasm, cytosol . Mainly cytosolic but when active detected in long filamentous structures (PubMed:25223282). Co-localizes with TNK2 in the cytosolic filaments (By similarity). .Expression:
Widely expressed.
- Western Blot analysis of HuvEc cells using CTPS Polyclonal Antibody diluted at 1:500
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