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CRMP-2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71115

  • Amount:

    100ul

  • Molecular Weight:

    62294Da

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human DRP-2. AA range:480-529

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of mouse brain cells using CRMP-2 Polyclonal Antibody

  • Gene Name:

    DPYSL2

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Dihydropyrimidinase-related protein 2 Human Gene Id:1808

  • Human Swiss Prot No:

    Q16555

  • Specificity:

    CRMP-2 Polyclonal Antibody detects endogenous levels of CRMP-2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DPYSL2; CRMP2; ULIP2; Dihydropyrimidinase-related protein 2; DRP-2; Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2

  • Observed Band(KD):

    62

  • Background:

    dihydropyrimidinase like 2(DPYSL2) Homo sapiens This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],

  • Function:

    function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4.,tissue specificity:Ubiquitous.,

  • Subcellular Location:

    cytoplasm,mitochondrion,cytosol,cytoskeleton,microtubule,membrane,dendrite,growth cone,neuronal cell body,terminal bouton,myelin sheath,protein complex,extracellular exosome,

  • Expression:

    Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Fetal liver,Test

  • Immunofluorescence analysis of HeLa cells, using DRP-2 Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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