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CRF Polyclonal Antibody
Datasheet
Catalog Number:
E20-71107Amount:
100ulMolecular Weight:
21422DaPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CRF. AA range:104-153Source:
Polyclonal, RabbitGene Name:
CRHDilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
- Immunohistochemistry analysis of CRF antibody in paraffin-embedded human lung carcinoma tissue.
Protein Name:
CorticoliberinHuman Gene Id:
1392Human Swiss Prot No:
P06850Mouse Swiss Prot No:
Q8CIT0Specificity:
CRF Polyclonal Antibody detects endogenous levels of CRF protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CRH; Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormoneBackground:
corticotropin releasing hormone(CRH) Homo sapiens This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation aFunction:
function:This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.,online information:Corticotropin-releasing hormone entry,similarity:Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.,Subcellular Location:
extracellular region,extracellular space,cytoplasm,varicosity,perikaryon,Expression:
Brain,
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