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CREB-2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71103

  • Amount:

    100ul

  • Molecular Weight:

    38590 DaObserved Band:38 KD

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized peptide derived from CREB-2 . at AA range: 160-240

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of A549 cells using CREB-2 Polyclonal Antibody

  • Gene Name:

    ATF4

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Cyclic AMP-dependent transcription factor ATF-4

  • Human Gene Id:

    468

  • Human Swiss Prot No:

    P18848

  • Mouse Gene Id:

    11911

  • Mouse Swiss Prot No:

    Q06507

  • Specificity:

    CREB-2 Polyclonal Antibody detects endogenous levels of CREB-2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ATF4; CREB2; TXREB; Cyclic AMP-dependent transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding prot

  • Background:

    activating transcription factor 4(ATF4) Homo sapiens This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provid

  • Function:

    function:Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subcellular location:Colocalizes with GABBR1 in hippocampal neuron dendritic membranes.,subunit:Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Binds DNA as a homo-or heterodimer. Interacts with the N-terminal region of CEP290.,

  • Subcellular Location:

    Nucleus . Nucleus speckle . Cytoplasm . Cell membrane . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772). .

  • Expression:

    Bladder,Colon,Fibroblast,Leukemic T-cell,Lung,Ovary,Placenta,

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Catalog Number

  • Amount:100ul
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CREB-2 Polyclonal Antibody | EnoGene Biotech Co. Ltd