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CRABP-II Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71094

  • Amount:

    100ul

  • Molecular Weight:

    15693 DaObserved Band:16 KD

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CRABP2. AA range:41-90

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using CRABP-II Polyclonal Antibody

  • Gene Name:

    CRABP2

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Cellular retinoic acid-binding protein 2

  • Human Gene Id:

    1382

  • Human Swiss Prot No:

    P29373

  • Mouse Gene Id:

    12904

  • Mouse Swiss Prot No:

    P22935

  • Rat Gene Id:

    1.00912e+008

  • Rat Swiss Prot No:

    P51673

  • Specificity:

    CRABP-II Polyclonal Antibody detects endogenous levels of CRABP-II protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CRABP2; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II

  • Background:

    This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010],

  • Function:

    domain:Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.,function:Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.,induction:By retinoic acid.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,subcellular location:Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.,subunit:Interacts with RXR and RARA (By similarity). Interacts with importin alpha.,

  • Subcellular Location:

    Cytoplasm. Endoplasmic reticulum. Nucleus. Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.

  • Expression:

    Colon,Placenta,

  • Western blot analysis of lysates from HT-29 cells, using CRABP2 Antibody. The lane on the right is blocked with the synthesized peptide.

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