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CPE Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71082

  • Amount:

    100ul

  • Molecular Weight:

    53151 DaObserved Band:53 Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CPE. AA range:271-320

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using CPE Polyclonal Antibody

  • Gene Name:

    CPE

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Carboxypeptidase E

  • Human Gene Id:

    1363

  • Human Swiss Prot No:

    P16870

  • Mouse Gene Id:

    12876

  • Mouse Swiss Prot No:

    Q00493

  • Rat Gene Id:

    25669

  • Rat Swiss Prot No:

    P15087

  • Specificity:

    CPE Polyclonal Antibody detects endogenous levels of CPE protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CPE; Carboxypeptidase E; CPE; Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase

  • Background:

    carboxypeptidase E(CPE) Homo sapiens This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015],

  • Function:

    catalytic activity:Release of C-terminal arginine or lysine residues from polypeptides.,cofactor:Binds 1 zinc ion per subunit.,function:Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.,similarity:Belongs to the peptidase M14 family.,subcellular location:Secretory granules of pancreatic islets, adrenal gland, pituitary and brain.,

  • Subcellular Location:

    [Isoform 1]: Cytoplasmic vesicle, secretory vesicle . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Secreted . Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. .

  • Expression:

    Brain,Colon,Eye,

  • Western Blot analysis of K562 cells using CPE Polyclonal Antibody

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Catalog Number

  • Amount:100ul
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