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COX17 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71071

  • Amount:

    100ul

  • Molecular Weight:

    6915 DaObserved Band:7 KD

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human COX17. AA range:1-50

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using COX17 Polyclonal Antibody

  • Gene Name:

    COX17

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Cytochrome c oxidase copper chaperone

  • Human Gene Id:

    10063

  • Human Swiss Prot No:

    Q14061

  • Mouse Swiss Prot No:

    P56394

  • Specificity:

    COX17 Polyclonal Antibody detects endogenous levels of COX17 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    COX17; Cytochrome c oxidase copper chaperone

  • Background:

    Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provi

  • Function:

    function:Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.,similarity:Belongs to the COX17 family.,tissue specificity:Ubiquitous.,

  • Subcellular Location:

    Mitochondrion intermembrane space . Cytoplasm .

  • Expression:

    Ubiquitous.

  • Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using COX17 Antibody. The picture on the right is blocked with the synthesized peptide.

  • Mouse Gene Id:

    12856

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