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Cell Signal Transduction Research Antibodies
COX10 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight48882Da
Protein NameProtoheme IX farnesyltransferase mitochondrial
Human Gene Id1352
Human Swiss Prot NoQ12887
Mouse Swiss Prot NoQ8CFY5
SpecificityCOX10 Polyclonal Antibody detects endogenous levels of COX10 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCOX10; Protoheme IX farnesyltransferase; mitochondrial; Heme O synthase
Observed Band(KD)49
Functiondisease:Defects in COX10 are a cause of cytochrome c oxidase deficiency (COX deficiency) [MIM:220110]. COX deficiency is a clinically heterogeneous disorder. The clinical features are ranging from isolated myopathy to severe multisystem disease, with onset from infancy to adulthood.,disease:Defects in COX10 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.,function:Converts protoheme IX and farnesyl diphosphate to heme O.,similarity:Belongs to the ubiA prenyltransferase family.,
Subcellular Locationmitochondrion,mitochondrial inner membrane,integral component of membrane,cytochrome complex,
ExpressionBrain,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human COX10. AA range:98-147
Gene NameCOX10
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
BackgroundCOX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor(COX10) Homo sapiens Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lys
Conjugated Antibody
This product is also available conjugated. Format: E20-71068-Conjugate. Price: $485 / Size: 100μl.
E20-71068-FITC$485 / 100μlE20-71068-Biotin$485 / 100μlE20-71068-HRP$485 / 100μlE20-71068-AP$485 / 100μlE20-71068-AF350$485 / 100μlE20-71068-AF405M$485 / 100μlE20-71068-AF488$485 / 100μlE20-71068-AF514$485 / 100μlE20-71068-AF532$485 / 100μlE20-71068-AF555$485 / 100μlE20-71068-AF568$485 / 100μlE20-71068-AF405S$485 / 100μlE20-71068-AF405L$485 / 100μlE20-71068-AF546$485 / 100μlE20-71068-AF594$485 / 100μlE20-71068-AF610$485 / 100μlE20-71068-AF635$485 / 100μlE20-71068-AF647$485 / 100μlE20-71068-AF680$485 / 100μlE20-71068-AF700$485 / 100μlE20-71068-AF750$485 / 100μlE20-71068-AF790$485 / 100μlE20-71068-APC$485 / 100μlE20-71068-PE$485 / 100μlE20-71068-Cy3$485 / 100μlE20-71068-Cy5$485 / 100μlE20-71068-Cy5.5$485 / 100μlE20-71068-Cy7$485 / 100μlE20-71068-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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