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Cortactin Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71062

  • Amount:

    100ul

  • Molecular Weight:

    61636(DA) Observed Band(KD)80

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Cortactin. AA range:388-437

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    CTTN

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Western blot analysis of lysates from HeLa cells, treated with H2O2, using Cortactin Antibody. The lane on the right is blocked with the synthesized peptide.

  • Protein Name:

    Src substrate cortactin

  • Human Gene Id:

    2017

  • Human Swiss Prot No:

    Q14247

  • Mouse Gene Id:

    13043

  • Mouse Swiss Prot No:

    Q60598

  • Specificity:

    Cortactin Polyclonal Antibody detects endogenous levels of Cortactin protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

  • Background:

    cortactin(CTTN) Homo sapiens This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010],

  • Function:

    function:May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.,online information:Cortactin entry,similarity:Contains 1 SH3 domain.,similarity:Contains 7 cortactin repeats.,subcellular location:Associated with membrane ruffles and lamellipodia.,subunit:Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity). Interacts with PLXDC2.,

  • Subcellular Location:

    ruffle,podosome,cytoplasm,Golgi apparatus,cytoskeleton,actin filament,plasma membrane,clathrin-coated pit,cell-cell adherens junction,focal adhesion,cell cortex,voltage-gated potassium channel complex,lamellipodium,growth

  • Expression:

    Coronary artery,Epithelium,Mammary gland,Placenta,Platelet,Testis,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Cortactin Polyclonal Antibody | EnoGene Biotech Co. Ltd