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Cell Signal Transduction Research Antibodies
Coronin 1A Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight51026Da
Protein NameCoronin-1A
Human Gene Id11151
Human Swiss Prot NoP31146
Mouse Gene Id12721
Mouse Swiss Prot NoO89053
Rat Gene Id155151
Rat Swiss Prot NoQ91ZN1
SpecificityCoronin 1A Polyclonal Antibody detects endogenous levels of Coronin 1A protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCORO1A; CORO1; Coronin-1A; Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO
Observed Band(KD)51
Functionfunction:May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.,similarity:Belongs to the WD repeat coronin family.,similarity:Contains 5 WD repeats.,subcellular location:In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.,subunit:Binds actin.,tissue specificity:Expressed in brain, thymus, spleen, bone marrow and lymph node. L
Subcellular Locationimmunological synapse,phagocytic cup,nucleus,cytoplasm,early endosome,cytosol,actin filament,plasma membrane,cell-cell junction,actin cytoskeleton,membrane,lamellipodium,axon,phagocytic vesicle membrane,
ExpressionBrain,Hippocampus,Keratinocyte,Kidney,Peripheral blood leukocyte,T-cell,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from Coronin 1A . at AA range: 150-230
Gene NameCORO1A
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Backgroundcoronin 1A(CORO1A) Homo sapiens This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-71061-Conjugate. Price: $485 / Size: 100μl.
E20-71061-FITC$485 / 100μlE20-71061-Biotin$485 / 100μlE20-71061-HRP$485 / 100μlE20-71061-AP$485 / 100μlE20-71061-AF350$485 / 100μlE20-71061-AF405M$485 / 100μlE20-71061-AF488$485 / 100μlE20-71061-AF514$485 / 100μlE20-71061-AF532$485 / 100μlE20-71061-AF555$485 / 100μlE20-71061-AF568$485 / 100μlE20-71061-AF405S$485 / 100μlE20-71061-AF405L$485 / 100μlE20-71061-AF546$485 / 100μlE20-71061-AF594$485 / 100μlE20-71061-AF610$485 / 100μlE20-71061-AF635$485 / 100μlE20-71061-AF647$485 / 100μlE20-71061-AF680$485 / 100μlE20-71061-AF700$485 / 100μlE20-71061-AF750$485 / 100μlE20-71061-AF790$485 / 100μlE20-71061-APC$485 / 100μlE20-71061-PE$485 / 100μlE20-71061-Cy3$485 / 100μlE20-71061-Cy5$485 / 100μlE20-71061-Cy5.5$485 / 100μlE20-71061-Cy7$485 / 100μlE20-71061-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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