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Connexin 4 Polyclonal Antibody
Datasheet
Catalog Number:
E20-71049Amount:
100ulSwiss-Prot No.:
Q5T442Molecular Weight:
47kd Observed Band 47kdApplications:
WB,IF/ICC,ELISAReactivity:
HumanPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CXG2. AA range:21-70Specificity/Sensitivity:
Connexin 47 Polyclonal Antibody detects endogenous levels of Connexin 47 protein.Storage/Stability:
-20°C/1 yearSource:
Rabbit
- Western Blot analysis of A549 cells using Connexin 47 Polyclonal Antibody
Gene Name:
GJC2Dilution:
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.Background:
gap junction protein gamma 2(GJC2) Homo sapiens This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1. [provided by RefSeq, Jul 2008],Gene ID:
57165Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azideFunction:
caution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in GJC2are the cause of Leukodystrophy hypomyelinating type 2 (HLD2) [MIM:608804]; also known as Pelizaeus-Merzbacher-like disease autosomal recessive type 1. HLD2 is anautosomal recessive hypomyelinating leukodystrophy characterized by nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria and progressive spasticity.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.,similarity:Belongs to the connexin family. Gamma-type subfamily.,subunit:A connexon is composed of a hexamer of connexins. Interacts with TJP1.,tissue specificity:Expressed in central nervous system,
- Immunofluorescence analysis of A549 cells, using CXG2 Antibody. The picture on the right is blocked with the synthesized peptide.
- Western blot analysis of lysates from A549 cells, using CXG2 Antibody. The lane on the right is blocked with the synthesized peptide.
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