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Cell Signal Transduction Research Antibodies
COL4A2 Polyclonal Antibody Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight167553Da
Protein NameCollagen alpha-2(IV) chain
Human Gene Id1284
Human Swiss Prot NoP08572
Mouse Gene Id12827
Mouse Swiss Prot NoP08122
SpecificityCOL4A2 Polyclonal Antibody detects endogenous levels of COL4A2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCOL4A2; Collagen alpha-2(IV) chain
Observed Band(KD)150
Functiondomain:Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.,function:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.,PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, lo
Subcellular Locationextracellular region,collagen type IV trimer,endoplasmic reticulum lumen,extracellular matrix,intracellular membrane-bounded organelle,extracellular exosome,
ExpressionEye,Hepatocyte,Placenta,Skin,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Collagen IV alpha2. AA range:151-200
Gene NameCOL4A2
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundcollagen type IV alpha 2 chain(COL4A2) Homo sapiens This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-71025-Conjugate. Price: $485 / Size: 100μl.
E20-71025-FITC$485 / 100μlE20-71025-Biotin$485 / 100μlE20-71025-HRP$485 / 100μlE20-71025-AP$485 / 100μlE20-71025-AF350$485 / 100μlE20-71025-AF405M$485 / 100μlE20-71025-AF488$485 / 100μlE20-71025-AF514$485 / 100μlE20-71025-AF532$485 / 100μlE20-71025-AF555$485 / 100μlE20-71025-AF568$485 / 100μlE20-71025-AF405S$485 / 100μlE20-71025-AF405L$485 / 100μlE20-71025-AF546$485 / 100μlE20-71025-AF594$485 / 100μlE20-71025-AF610$485 / 100μlE20-71025-AF635$485 / 100μlE20-71025-AF647$485 / 100μlE20-71025-AF680$485 / 100μlE20-71025-AF700$485 / 100μlE20-71025-AF750$485 / 100μlE20-71025-AF790$485 / 100μlE20-71025-APC$485 / 100μlE20-71025-PE$485 / 100μlE20-71025-Cy3$485 / 100μlE20-71025-Cy5$485 / 100μlE20-71025-Cy5.5$485 / 100μlE20-71025-Cy7$485 / 100μlE20-71025-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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