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COL4A1 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71024

  • Amount:

    100ul

  • Molecular Weight:

    160615Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Collagen IV. AA range:11-60

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of mouse-musle cells using COL4A1 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    COL4A1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Collagen alpha-1(IV) chain

  • Human Gene Id:

    1282

  • Human Swiss Prot No:

    P02462

  • Mouse Gene Id:

    12826

  • Mouse Swiss Prot No:

    P02463

  • Specificity:

    COL4A1 Polyclonal Antibody detects endogenous levels of COL4A1 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    COL4A1; Collagen alpha-1(IV) chain

  • Observed Band(KD):

    160

  • Background:

    This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

  • Function:

    disease:Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria and bilateral large cysts. Histologic analysis revealed complex bas

  • Subcellular Location:

    Secreted, extracellular space, extracellular matrix, basement membrane .

  • Expression:

    Highly expressed in placenta.Products Images

  • Western Blot analysis of mouse-musle cells using COL4A1 Polyclonal Antibody diluted at 1:500

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Catalog Number

  • Amount:100ul
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COL4A1 Polyclonal Antibody | EnoGene Biotech Co. Ltd