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Cell Signal Transduction Research Antibodies
COL3A1 Polyclonal AntibodyAntibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight138564Da
Protein NameCollagen alpha-1(III) chain
Human Gene Id1281
Human Swiss Prot NoP02461
Mouse Gene Id12825
Mouse Swiss Prot NoP08121
Rat Gene Id84032
Rat Swiss Prot NoP13941
SpecificityCOL3A1 Polyclonal Antibody detects endogenous levels of COL3A1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCOL3A1; Collagen alpha-1(III) chain
Functiondisease:Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [MIM:130020]; also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity.,disease:Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [MIM:100070]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells.,disease:Defects in COL3A1 are the cause of Ehlers-Danlos syndrome t
Subcellular Locationextracellular region,collagen trimer,collagen type III trimer,extracellular space,endoplasmic reticulum lumen,extracellular matrix,
ExpressionColon carcinoma,Liver,Placenta,Skin fibroblast,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Collagen III. AA range:81-130
Gene NameCOL3A1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundcollagen type III alpha 1 chain(COL3A1) Homo sapiens This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-71023-Conjugate. Price: $485 / Size: 100μl.
E20-71023-FITC$485 / 100μlE20-71023-Biotin$485 / 100μlE20-71023-HRP$485 / 100μlE20-71023-AP$485 / 100μlE20-71023-AF350$485 / 100μlE20-71023-AF405M$485 / 100μlE20-71023-AF488$485 / 100μlE20-71023-AF514$485 / 100μlE20-71023-AF532$485 / 100μlE20-71023-AF555$485 / 100μlE20-71023-AF568$485 / 100μlE20-71023-AF405S$485 / 100μlE20-71023-AF405L$485 / 100μlE20-71023-AF546$485 / 100μlE20-71023-AF594$485 / 100μlE20-71023-AF610$485 / 100μlE20-71023-AF635$485 / 100μlE20-71023-AF647$485 / 100μlE20-71023-AF680$485 / 100μlE20-71023-AF700$485 / 100μlE20-71023-AF750$485 / 100μlE20-71023-AF790$485 / 100μlE20-71023-APC$485 / 100μlE20-71023-PE$485 / 100μlE20-71023-Cy3$485 / 100μlE20-71023-Cy5$485 / 100μlE20-71023-Cy5.5$485 / 100μlE20-71023-Cy7$485 / 100μlE20-71023-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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