COL17A1 Polyclonal Antibody Antibody

Name: COL17A1 Polyclonal Antibody Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-71014
Price: 225 USD
Availability: InStock

E20-71014Cite ID: EN0051147Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight150419Da

Protein NameCollagen alpha-1(XVII) chain

Human Gene Id1308

Human Swiss Prot NoQ9UMD9

Mouse Gene Id12821

Mouse Swiss Prot NoQ07563

SpecificityCOL17A1 Polyclonal Antibody detects endogenous levels of COL17A1 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameCOL17A1; BP180; BPAG2; Collagen alpha-1(XVII) chain; 180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2

Functiondisease:Defects in COL17A1 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.,function:May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.,function:The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.,miscellaneous:Both the 120 kDa linear IgA disease antigen and the 97 kDa linear IgA disease antigen of COL17A1, represent major antigenic targets of autoantibodies in patients with linear IgA disease (LAD). LAD is a subepidermal blistering disorder characterized by tissue-bound and circulating I

Subcellular Locationextracellular region,proteinaceous extracellular matrix,collagen trimer,basement membrane,endoplasmic reticulum lumen,plasma membrane,integral component of plasma membrane,cell-cell junction,integral component of membrane,hemidesmosom

ExpressionEpithelium,Foreskin,Pancreas,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from COL17A1 . at AA range: 1-80

Gene NameCOL17A1

DilutionImmunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Backgroundcollagen type XVII alpha 1 chain(COL17A1) Homo sapiens This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-71014-Conjugate. Price: $485 / Size: 100μl.

E20-71014-FITC$485 / 100μlE20-71014-Biotin$485 / 100μlE20-71014-HRP$485 / 100μlE20-71014-AP$485 / 100μlE20-71014-AF350$485 / 100μlE20-71014-AF405M$485 / 100μlE20-71014-AF488$485 / 100μlE20-71014-AF514$485 / 100μlE20-71014-AF532$485 / 100μlE20-71014-AF555$485 / 100μlE20-71014-AF568$485 / 100μlE20-71014-AF405S$485 / 100μlE20-71014-AF405L$485 / 100μlE20-71014-AF546$485 / 100μlE20-71014-AF594$485 / 100μlE20-71014-AF610$485 / 100μlE20-71014-AF635$485 / 100μlE20-71014-AF647$485 / 100μlE20-71014-AF680$485 / 100μlE20-71014-AF700$485 / 100μlE20-71014-AF750$485 / 100μlE20-71014-AF790$485 / 100μlE20-71014-APC$485 / 100μlE20-71014-PE$485 / 100μlE20-71014-Cy3$485 / 100μlE20-71014-Cy5$485 / 100μlE20-71014-Cy5.5$485 / 100μlE20-71014-Cy7$485 / 100μlE20-71014-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.