Product Information
Molecular Weight157751Da
Protein NameCollagen alpha-1(XVI) chain
Human Gene Id1307
Human Swiss Prot NoQ07092
Mouse Gene Id107581
Mouse Swiss Prot NoQ8BLX7
SpecificityCOL16A1 Polyclonal Antibody detects endogenous levels of COL16A1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCOL16A1; FP1572; Collagen alpha-1(XVI) chain
Functiondevelopmental stage:Transiently elevated expression during gestation, and decrease at term.,domain:This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible.,function:Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.,PTM:Glycosylated.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,subunit:Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB
Subcellular Locationextracellular region,proteinaceous extracellular matrix,collagen type XVI trimer,endoplasmic reticulum lumen,
ExpressionFibroblast,Placenta,Spleen,
Backgroundcollagen type XVI alpha 1 chain(COL16A1) Homo sapiens This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. [provided by RefSeq, Jul 2008],