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COL11A2 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-71009

  • Amount:

    100ul

  • Molecular Weight:

    171775Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Collagen XI alpha2. AA range:1211-1260

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using COL11A2 Polyclonal Antibody diluted at 1:500

  • Gene Name:

    COL11A2

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Collagen alpha-2(XI) chain

  • Human Gene Id:

    1302

  • Human Swiss Prot No:

    P13942

  • Mouse Gene Id:

    12815

  • Mouse Swiss Prot No:

    Q64739

  • Specificity:

    COL11A2 Polyclonal Antibody detects endogenous levels of COL11A2 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    COL11A2; Collagen alpha-2(XI) chain

  • Observed Band(KD):

    171

  • Background:

    collagen type XI alpha 2 chain(COL11A2) Homo sapiens This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009],

  • Function:

    alternative products:Isoforms lack exons 6, 7 or 8 or a combination of these exons. Experimental confirmation may be lacking for some isoforms,disease:Defects in COL11A2 are the cause of autosomal recessive otospondylomegaepiphyseal dysplasia (OSMED) [MIM:215150]. OSMED is a skeletal dysplasia accompanied by severe hearing loss. The phenotype overlaps that of autosomal dominant skeletal disorders (Stickler and Marshall syndromes) but can be distinguished by disproportionately short limbs and lack of ocular involvement.,disease:Defects in COL11A2 are the cause of non-syndromic sensorineural deafness autosomal dominant type 13 (DFNA13) [MIM:601868]. DFNA13 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,disease:Defects in C

  • Subcellular Location:

    Secreted, extracellular space, extracellular matrix .

  • Expression:

    Cartilage,Skin,Uterus,Products Images

  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Collagen XI alpha2 Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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COL11A2 Polyclonal Antibody | EnoGene Biotech Co. Ltd