World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
CNG-1 Polyclonal AntibodyAntibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight79126Da
Protein NamecGMP-gated cation channel alpha-1
Human Gene Id1259
Human Swiss Prot NoP29973
Mouse Gene Id12788
Mouse Swiss Prot NoP29974
Rat Gene Id85259
Rat Swiss Prot NoQ62927
SpecificityCNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCNGA1; CNCG; CNCG1; cGMP-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel; photoreceptor; Rod photoreceptor cG
Observed Band(KD)80
Functioncaution:It is uncertain whether Met-1 or Met-5 is the initiator.,disease:Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subuni
Subcellular Locationplasma membrane,integral component of plasma membrane,integral component of membrane,photoreceptor outer segment membrane,
ExpressionRetina,Spleen,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human CNGA1. AA range:401-450
Gene NameCNGA1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Backgroundcyclic nucleotide gated channel alpha 1(CNGA1) Homo sapiens The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-70995-Conjugate. Price: $485 / Size: 100μl.
E20-70995-FITC$485 / 100μlE20-70995-Biotin$485 / 100μlE20-70995-HRP$485 / 100μlE20-70995-AP$485 / 100μlE20-70995-AF350$485 / 100μlE20-70995-AF405M$485 / 100μlE20-70995-AF488$485 / 100μlE20-70995-AF514$485 / 100μlE20-70995-AF532$485 / 100μlE20-70995-AF555$485 / 100μlE20-70995-AF568$485 / 100μlE20-70995-AF405S$485 / 100μlE20-70995-AF405L$485 / 100μlE20-70995-AF546$485 / 100μlE20-70995-AF594$485 / 100μlE20-70995-AF610$485 / 100μlE20-70995-AF635$485 / 100μlE20-70995-AF647$485 / 100μlE20-70995-AF680$485 / 100μlE20-70995-AF700$485 / 100μlE20-70995-AF750$485 / 100μlE20-70995-AF790$485 / 100μlE20-70995-APC$485 / 100μlE20-70995-PE$485 / 100μlE20-70995-Cy3$485 / 100μlE20-70995-Cy5$485 / 100μlE20-70995-Cy5.5$485 / 100μlE20-70995-Cy7$485 / 100μlE20-70995-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits