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CLN6 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70977Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CLN6. AA range:221-270Source:
Polyclonal, RabbitGene Name:
CLN6Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Western blot analysis of lysates from HeLa cells, using CLN6 Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
ceroid-lipofuscinosis, neuronal 6, late infantile, variant(CLN6) Homo sapiens This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008],Protein Name:
Ceroid-lipofuscinosis neuronal protein 6Human Gene Id:
54982Human Swiss Prot No:
Q9NWW5Specificity:
CLN6 Polyclonal Antibody detects endogenous levels of CLN6 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CLN6; Ceroid-lipofuscinosis neuronal protein 6; Protein CLN6MolecularWeight(Da):
35919Observed Band(KD):
40Function:
disease:Defects in CLN6 are the cause of variant late-onset infantile neuronal ceroid lipofuscinosis (vLINCL) [MIM:601780].,online information:Neural Ceroid Lipofuscinoses mutation db,Subcellular Location:
endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,membrane,integral component of membrane,Expression:
B-cell,Colon,Skin,
- Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using CLN6 Antibody. The picture on the right is blocked with the synthesized peptide.
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