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CLIC6 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70966Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CLIC6. AA range:411-460Source:
Polyclonal, RabbitGene Name:
CLIC6Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
- Western blot analysis of CLIC6 Antibody. The lane on the right is blocked with the CLIC6 peptide.
Background:
chloride intracellular channel 6(CLIC6) Homo sapiens This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015],Protein Name:
Chloride intracellular channel protein 6Human Gene Id:
54102Human Swiss Prot No:
Q96NY7Mouse Swiss Prot No:
Q8BHB9Specificity:
CLIC6 Polyclonal Antibody detects endogenous levels of CLIC6 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CLIC6; CLIC1L; Chloride intracellular channel protein 6; ParchorinMolecularWeight(Da):
73012Observed Band(KD):
75Function:
domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.,function:May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.,PTM:Phosphorylated.,similarity:Belongs to the chloride channel CLIC family.,similarity:Contains 1 GST C-terminal domain.,subcellular location:Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane.,subunit:Interacts with dopamine receptors DRD2, DRD3 and DRD4.,tissue specificity:Expressed in brain, placenta, pancreas and liver.,Subcellular Location:
nucleus,cytoplasm,plasma membrane,chloride channel complex,extracellular exosome,Expression:
Brain,Small intestine,
- Western blot analysis of the lysates from HepG2 cells using CLIC6 antibody.
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Catalog Number
- Amount:100ul
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