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Cell Signal Transduction Research Antibodies
Claudin-4 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight22077Da
Protein NameClaudin-4
Human Gene Id1364
Human Swiss Prot NoO14493
Mouse Swiss Prot NoO35054
SpecificityClaudin-4 Polyclonal Antibody detects endogenous levels of Claudin-4 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCLDN4; CPER; CPETR1; WBSCR8; Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein
Observed Band(KD)28
Functiondisease:Haploinsufficiency of CLDN4 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
Subcellular Locationplasma membrane,integral component of plasma membrane,bicellular tight junction,basal plasma membrane,integral component of membrane,apical plasma membrane,apicolateral plasma membrane,lateral plasma membrane,
ExpressionColon,Fetal brain,Trachea,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Claudin 4. AA range:160-209
Gene NameCLDN4
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Backgroundclaudin 4(CLDN4) Homo sapiens The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013],
Conjugated Antibody
This product is also available conjugated. Format: E20-70950-Conjugate. Price: $485 / Size: 100μl.
E20-70950-FITC$485 / 100μlE20-70950-Biotin$485 / 100μlE20-70950-HRP$485 / 100μlE20-70950-AP$485 / 100μlE20-70950-AF350$485 / 100μlE20-70950-AF405M$485 / 100μlE20-70950-AF488$485 / 100μlE20-70950-AF514$485 / 100μlE20-70950-AF532$485 / 100μlE20-70950-AF555$485 / 100μlE20-70950-AF568$485 / 100μlE20-70950-AF405S$485 / 100μlE20-70950-AF405L$485 / 100μlE20-70950-AF546$485 / 100μlE20-70950-AF594$485 / 100μlE20-70950-AF610$485 / 100μlE20-70950-AF635$485 / 100μlE20-70950-AF647$485 / 100μlE20-70950-AF680$485 / 100μlE20-70950-AF700$485 / 100μlE20-70950-AF750$485 / 100μlE20-70950-AF790$485 / 100μlE20-70950-APC$485 / 100μlE20-70950-PE$485 / 100μlE20-70950-Cy3$485 / 100μlE20-70950-Cy5$485 / 100μlE20-70950-Cy5.5$485 / 100μlE20-70950-Cy7$485 / 100μlE20-70950-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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