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Claudin-11 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70945Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range:158-207Source:
Polyclonal, RabbitGene Name:
CLDN11Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
- Western blot analysis of lysates from mouse brain, using Claudin 11 Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
claudin 11(CLDN11) Homo sapiens This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoProtein Name:
Claudin-11Human Gene Id:
5010Human Swiss Prot No:
O75508Mouse Gene Id:
18417Mouse Swiss Prot No:
Q60771Rat Swiss Prot No:
Q99P82Specificity:
Claudin-11 Polyclonal Antibody detects endogenous levels of Claudin-11 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific proteinMolecularWeight(Da):
21993Observed Band(KD):
20Function:
function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Interacts with tetraspanin-3/TSPAN3.,Subcellular Location:
plasma membrane,bicellular tight junction,integral component of membrane,myelin sheath,basal part of cell,extracellular exosome,Expression:
Lung,Spinal cord,
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