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Cell Signal Transduction Research Antibodies
Citron Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight231431Da
Protein NameCitron Rho-interacting kinase
Human Gene Id11113
Human Swiss Prot NoO14578
Mouse Swiss Prot NoP49025
SpecificityCitron Polyclonal Antibody detects endogenous levels of Citron protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCIT; CRIK; KIAA0949; STK21; Citron Rho-interacting kinase; CRIK; Serine/threonine-protein kinase 21
Functioncatalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Required for KIF14 localization to the central spindle and midbody. May play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 CNH domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,sim
Subcellular Locationintracellular,cytosol,plasma membrane,membrane,Golgi cisterna,neuronal cell body,
ExpressionBrain,Epithelium,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human CTRO. AA range:1011-1060
Gene NameCIT
DilutionImmunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Backgroundcitron rho-interacting serine/threonine kinase(CIT) Homo sapiens This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-70931-Conjugate. Price: $485 / Size: 100μl.
E20-70931-FITC$485 / 100μlE20-70931-Biotin$485 / 100μlE20-70931-HRP$485 / 100μlE20-70931-AP$485 / 100μlE20-70931-AF350$485 / 100μlE20-70931-AF405M$485 / 100μlE20-70931-AF488$485 / 100μlE20-70931-AF514$485 / 100μlE20-70931-AF532$485 / 100μlE20-70931-AF555$485 / 100μlE20-70931-AF568$485 / 100μlE20-70931-AF405S$485 / 100μlE20-70931-AF405L$485 / 100μlE20-70931-AF546$485 / 100μlE20-70931-AF594$485 / 100μlE20-70931-AF610$485 / 100μlE20-70931-AF635$485 / 100μlE20-70931-AF647$485 / 100μlE20-70931-AF680$485 / 100μlE20-70931-AF700$485 / 100μlE20-70931-AF750$485 / 100μlE20-70931-AF790$485 / 100μlE20-70931-APC$485 / 100μlE20-70931-PE$485 / 100μlE20-70931-Cy3$485 / 100μlE20-70931-Cy5$485 / 100μlE20-70931-Cy5.5$485 / 100μlE20-70931-Cy7$485 / 100μlE20-70931-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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