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CIITA Polyclonal Antibody
Datasheet
Catalog Number:
E20-70929Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CIITA. AA range:706-755Source:
Polyclonal, RabbitGene Name:
CIITADilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
- Western blot analysis of lysates from K562 cells, using CIITA Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
class II major histocompatibility complex transactivator(CIITA) Homo sapiens This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardiProtein Name:
MHC class II transactivatorHuman Gene Id:
4261Human Swiss Prot No:
P33076Mouse Gene Id:
12265Mouse Swiss Prot No:
P79621Specificity:
CIITA Polyclonal Antibody detects endogenous levels of CIITA protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CIITA; MHC2TA; MHC class II transactivator; CIITAMolecularWeight(Da):
123457Observed Band(KD):
123Function:
disease:Defects in CIITA are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.,function:Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promSubcellular Location:
nucleoplasm,cell surface,PML body,
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Catalog Number
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