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CHST6 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70921Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CHST6. AA range:331-380Source:
Polyclonal, RabbitGene Name:
CHST6Dilution:
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
- Immunofluorescence analysis of A549 cells, using CHST6 Antibody. The picture on the right is blocked with the synthesized peptide.
Background:
carbohydrate sulfotransferase 6(CHST6) Homo sapiens The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). [provided by RefSeq, Jan 2010],Protein Name:
Carbohydrate sulfotransferase 6Human Gene Id:
4166Human Swiss Prot No:
Q9GZX3Specificity:
CHST6 Polyclonal Antibody detects endogenous levels of CHST6 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CHST6; Carbohydrate sulfotransferase 6; Corneal N-acetylglucosamine-6-O-sulfotransferase; C-GlcNAc6ST; hCGn6ST; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta; GST4-beta; N-acetylglucosamine 6-O-sulfotransferaMolecularWeight(Da):
44099Function:
caution:PubMed:12824236 reported a Gly-204 variant, however according to their results reported in figure 1, it is a Gln-204 variant.,disease:Defects in CHST6 are the cause of macular corneal dystrophy (MCD) [MIM:217800]. MCD is an autosomal recessive disease characterized by corneal opacities. Onset occurs in the first decade, usually between ages 5 and 9. The disorder is progressive. Minute, gray, punctate opacities develop. Corneal sensitivity is usually reduced. Painful attacks with photophobia, foreign body sensations, and recurrent erosions occur in most patients. There are different types of MCD: MCD type I, in which there is a virtual absence of sulfated keratan sulfate (KS) in the serum and cornea, as determined by KS-specific antibodies; and MCD type II, in which the normal sulfated KS-antibody response is present in cornea and serum. MCD type I patients usually have a homozygoSubcellular Location:
Golgi membrane,Golgi apparatus,integral component of membrane,Expression:
Lung,
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Catalog Number
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