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CHOP Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70911

  • Amount:

    100ul

  • Molecular Weight:

    19175Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GADD153. AA range:91-140

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using CHOP Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    DDIT3

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    DNA damage-inducible transcript 3 protein

  • Human Gene Id:

    1649

  • Human Swiss Prot No:

    P35638

  • Mouse Gene Id:

    13198

  • Mouse Swiss Prot No:

    P35639

  • Rat Swiss Prot No:

    Q62857

  • Specificity:

    CHOP Polyclonal Antibody detects endogenous levels of CHOP protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    DDIT3; CHOP; CHOP10; GADD153; DNA damage-inducible transcript 3 protein; DDIT-3; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; Growth arrest and DNA damage-inducible protein GADD153

  • Observed Band(KD):

    26

  • Background:

    This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010],

  • Function:

    disease:A chromosomal aberration involving DDIT3 is found in a form of malignant myxoid liposarcoma [MIM:126337]. Translocation t(12;16)(q13;p11) with FUS.,function:Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer.,

  • Subcellular Location:

    Cytoplasm . Nucleus . Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. .

  • Expression:

    Muscle,Skeletal muscle,Products Images

  • Western Blot analysis of RAT-HEART cells using CHOP Polyclonal Antibody diluted at 1:1000

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Catalog Number

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CHOP Polyclonal Antibody | EnoGene Biotech Co. Ltd