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c-Fms Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70878

  • Amount:

    100ul

  • Molecular Weight:

    107984Da

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CSFR. AA range:531-580

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of COLO cells using c-Fms Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    CSF1R

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Macrophage colony-stimulating factor 1 receptor

  • Human Gene Id:

    1436

  • Human Swiss Prot No:

    P07333

  • Mouse Gene Id:

    12978

  • Mouse Swiss Prot No:

    P09581

  • Specificity:

    c-Fms Polyclonal Antibody detects endogenous levels of c-Fms protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD antigen CD115

  • Observed Band(KD):

    107

  • Background:

    colony stimulating factor 1 receptor(CSF1R) Homo sapiens The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with INPPL1/SHIP2 and THOC5.,tissue specificity:Expressed in bone marrow and in differentiated blood mononuclear cells.,

  • Subcellular Location:

    intracellular,plasma membrane,integral component of plasma membrane,cell surface,membrane,integral component of membrane,CSF1-CSF1R complex,

  • Expression:

    Brain,Placenta,Plasma,

  • Western Blot analysis of HEPG2 using c-Fms Polyclonal Antibody diluted at 1:1000

  • Immunofluorescence analysis of HeLa cells, using CSFR Antibody. The picture on the right is blocked with the synthesized peptide.

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Catalog Number

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c-Fms Polyclonal Antibody | EnoGene Biotech Co. Ltd