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c-Fgr Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70875

  • Amount:

    100ul

  • Molecular Weight:

    59479Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human N-ternal FGR. AA range:61-110

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using c-Fgr Polyclonal Antibody

  • Gene Name:

    FGR

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Tyrosine-protein kinase Fgr

  • Human Gene Id:

    2268

  • Human Swiss Prot No:

    P09769

  • Mouse Gene Id:

    14191

  • Mouse Swiss Prot No:

    P14234

  • Rat Gene Id:

    79113

  • Rat Swiss Prot No:

    Q6P6U0

  • Specificity:

    c-Fgr Polyclonal Antibody detects endogenous levels of c-Fgr protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    FGR; SRC2; Tyrosine-protein kinase Fgr; Gardner-Rasheed feline sarcoma viral; v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr

  • Observed Band(KD):

    55

  • Background:

    This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008],

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subunit:Binds PTPNS1.,

  • Subcellular Location:

    Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane . Mitochondrion intermembrane space . Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. .

  • Expression:

    Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.Products Images

  • Western blot analysis of lysates from HUVEC and COLO205 cells, using FGR Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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c-Fgr Polyclonal Antibody | EnoGene Biotech Co. Ltd