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CEP170 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70858

  • Amount:

    100ul

  • Molecular Weight:

    175293Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CEP170. AA range:701-750

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using CEP170 Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    CEP170

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Protein Name:

    Centrosomal protein of 170 kDa

  • Human Gene Id:

    9859

  • Human Swiss Prot No:

    Q5SW79

  • Mouse Swiss Prot No:

    Q6A065

  • Specificity:

    CEP170 Polyclonal Antibody detects endogenous levels of CEP170 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CEP170; FAM68A; KAB; KIAA0470; Centrosomal protein of 170 kDa; Cep170; KARP-1-binding protein; KARP1-binding protein

  • Observed Band(KD):

    160

  • Background:

    centrosomal protein 170(CEP170) Homo sapiens The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008],

  • Function:

    function:Plays a role in microtubule organization.,PTM:Phosphorylated; probably by PLK1. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CEP170 family.,similarity:Contains 1 FHA domain.,subcellular location:Associated with the mature mother centriole. Associated with spindle microtubules during mitosis.,subunit:Interacts with PLK1.,

  • Subcellular Location:

    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, spindle . Associated with the mature mother centriole. Associated with spindle microtubules during mitosis. Localizes to the distal appendage region of the centriole (PubMed:31789463). Localizes at the centriole proximal ends (PubMed:31789463). .

  • Expression:

    Brain,Cervix carcinoma,Epithelium,Skin,Testis,

  • Western Blot analysis of AD293 cells using CEP170 Polyclonal Antibody diluted at 1:1000

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Catalog Number

  • Amount:100ul
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CEP170 Polyclonal Antibody | EnoGene Biotech Co. Ltd