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Centrobin Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70855

  • Amount:

    100ul

  • Molecular Weight:

    101253Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CNTROB. AA range:591-640

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Centrobin Polyclonal Antibody

  • Gene Name:

    CNTROB

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Centrobin

  • Human Gene Id:

    116840

  • Human Swiss Prot No:

    Q8N137

  • Mouse Swiss Prot No:

    Q8CB62

  • Specificity:

    Centrobin Polyclonal Antibody detects endogenous levels of Centrobin protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CNTROB; LIP8; PP1221; Centrobin; Centrosomal BRCA2-interacting protein; LYST-interacting protein 8

  • Observed Band(KD):

    100

  • Background:

    This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],

  • Function:

    developmental stage:Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.,function:Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Wrong choice of frame.,subcellular location:Centriole-associated, asymmetrically localizes to the daughter centriole.,subunit:Interacts with LYST.,tissue specificity:Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.,

  • Subcellular Location:

    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Centriole-associated, asymmetrically localizes to the daughter centriole.

  • Expression:

    Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.

  • Immunohistochemistry analysis of paraffin-embedded human brain, using CNTROB Antibody. The picture on the right is blocked with the synthesized peptide.

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