Product Information
Molecular Weight33510 Da
Protein NameHomeobox protein CDX-2
Human Gene Id1045
Human Swiss Prot NoQ99626
Mouse Gene Id12591
Mouse Swiss Prot NoP43241
SpecificityCdx2 Polyclonal Antibody detects endogenous levels of Cdx2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCDX2; CDX3; Homeobox protein CDX-2; CDX-3; Caudal-type homeobox protein 2
Observed Band(KD)34
Functionfunction:Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.,PTM:Phosphorylation of Ser-60 mediates the transactivation capacity.,similarity:Belongs to the Caudal homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,
Subcellular Locationcondensed nuclear chromosome,nucleus,nucleoplasm,transcriptional repressor complex,protein complex,
ExpressionColon,Colon carcinoma,
Backgroundcaudal type homeobox 2(CDX2) Homo sapiens This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012],