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Cell Signal Transduction Research Antibodies
SEMA3A Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight23805 Da
Protein NameCyclin-dependent kinase inhibitor 3
Human Gene Id1033
Human Swiss Prot NoQ16667
Mouse Gene Id72391
Mouse Swiss Prot NoQ810P3
SpecificityCDKN3 Polyclonal Antibody detects endogenous levels of CDKN3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCDKN3; CDI1; CIP2; KAP; Cyclin-dependent kinase inhibitor 3; CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase
Observed Band(KD)23
Functioncatalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550].,function:May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.,induction:Up-regulated in breast and prostate cancer cells.,similarity:Belongs to the protein-tyrosine phosphatase family.,subunit:Interacts with cyclin-dependent kinases such as CDC2, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.,
Subcellular Locationnucleus,cytoplasm,perinuclear region of cytoplasm,
ExpressionRetinoblastoma,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human CDKN3. AA range:31-80
Gene NameCDKN3
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundcyclin dependent kinase inhibitor 3(CDKN3) Homo sapiens The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-70843-Conjugate. Price: $485 / Size: 100μl.
E20-70843-FITC$485 / 100μlE20-70843-Biotin$485 / 100μlE20-70843-HRP$485 / 100μlE20-70843-AP$485 / 100μlE20-70843-AF350$485 / 100μlE20-70843-AF405M$485 / 100μlE20-70843-AF488$485 / 100μlE20-70843-AF514$485 / 100μlE20-70843-AF532$485 / 100μlE20-70843-AF555$485 / 100μlE20-70843-AF568$485 / 100μlE20-70843-AF405S$485 / 100μlE20-70843-AF405L$485 / 100μlE20-70843-AF546$485 / 100μlE20-70843-AF594$485 / 100μlE20-70843-AF610$485 / 100μlE20-70843-AF635$485 / 100μlE20-70843-AF647$485 / 100μlE20-70843-AF680$485 / 100μlE20-70843-AF700$485 / 100μlE20-70843-AF750$485 / 100μlE20-70843-AF790$485 / 100μlE20-70843-APC$485 / 100μlE20-70843-PE$485 / 100μlE20-70843-Cy3$485 / 100μlE20-70843-Cy5$485 / 100μlE20-70843-Cy5.5$485 / 100μlE20-70843-Cy7$485 / 100μlE20-70843-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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