World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Cdc42EP2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight22484 Da
Protein NameCdc42 effector protein 2
Human Gene Id10435
Human Swiss Prot NoO14613
Mouse Gene Id104252
Mouse Swiss Prot NoQ8JZX9
Rat Gene Id309175
Rat Swiss Prot NoQ5PQP4
SpecificityCdc42EP2 Polyclonal Antibody detects endogenous levels of Cdc42EP2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCDC42EP2; BORG1; CEP2; Cdc42 effector protein 2; Binder of Rho GTPases 1
Observed Band(KD)28
Functiondomain:The CRIB domain mediates interaction with CDC42.,function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.,similarity:Belongs to the BORG/CEP family.,similarity:Contains 1 CRIB domain.,subunit:Interacts with RHOQ and CDC42 in a GTP-dependent manner, and with SEPT7.,tissue specificity:Highly expressed in the heart. Weakly expressed in the pancreas and liver.,
Subcellular Locationcytoplasm,cytosol,plasma membrane,endomembrane system,microtubule cytoskeleton,membrane,
ExpressionBrain,Embryo,Heart,Lung,Pancreas,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human BORG1. AA range:10-59
Gene NameCDC42EP2
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
BackgroundCDC42 effector protein 2(CDC42EP2) Homo sapiens CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-70808-Conjugate. Price: $485 / Size: 100μl.
E20-70808-FITC$485 / 100μlE20-70808-Biotin$485 / 100μlE20-70808-HRP$485 / 100μlE20-70808-AP$485 / 100μlE20-70808-AF350$485 / 100μlE20-70808-AF405M$485 / 100μlE20-70808-AF488$485 / 100μlE20-70808-AF514$485 / 100μlE20-70808-AF532$485 / 100μlE20-70808-AF555$485 / 100μlE20-70808-AF568$485 / 100μlE20-70808-AF405S$485 / 100μlE20-70808-AF405L$485 / 100μlE20-70808-AF546$485 / 100μlE20-70808-AF594$485 / 100μlE20-70808-AF610$485 / 100μlE20-70808-AF635$485 / 100μlE20-70808-AF647$485 / 100μlE20-70808-AF680$485 / 100μlE20-70808-AF700$485 / 100μlE20-70808-AF750$485 / 100μlE20-70808-AF790$485 / 100μlE20-70808-APC$485 / 100μlE20-70808-PE$485 / 100μlE20-70808-Cy3$485 / 100μlE20-70808-Cy5$485 / 100μlE20-70808-Cy5.5$485 / 100μlE20-70808-Cy7$485 / 100μlE20-70808-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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