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Cdc37 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70805

  • Amount:

    100ul

  • Molecular Weight:

    44468Da

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat;Monkeyt

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CDC37. AA range:1-50

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Cdc37 Polyclonal Antibody

  • Gene Name:

    CDC37

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Hsp90 co-chaperone Cdc37

  • Human Gene Id:

    11140

  • Human Swiss Prot No:

    Q16543

  • Mouse Gene Id:

    12539

  • Mouse Swiss Prot No:

    Q61081

  • Rat Gene Id:

    114562

  • Rat Swiss Prot No:

    Q63692

  • Specificity:

    Cdc37 Polyclonal Antibody detects endogenous levels of Cdc37 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CDC37; CDC37A; Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37

  • Observed Band(KD):

    44

  • Background:

    The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008],

  • Function:

    function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.,

  • Subcellular Location:

    Cytoplasm .

  • Expression:

    Lymph,Placenta,

  • Western Blot analysis of MCF7 cells using Cdc37 Polyclonal Antibody

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Catalog Number

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