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Cdc23 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70792Amount:
100ulMolecular Weight:
68286DaApplications:
WB;ELISAReactivity:
Human;Mouse;MonkeyPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human APC8. AA range:251-300Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using Cdc23 Polyclonal Antibody diluted at 1:2000
Gene Name:
CDC23Dilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.Protein Name:
Cell division cycle protein 23 homologHuman Gene Id:
8697Human Swiss Prot No:
Q9UJX2Mouse Gene Id:
52563Mouse Swiss Prot No:
Q8BGZ4Specificity:
Cdc23 Polyclonal Antibody detects endogenous levels of Cdc23 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CDC23; ANAPC8; Cell division cycle protein 23 homolog; Anaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8Observed Band(KD):
69Background:
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008],Function:
function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Thr-556 occurs specifically during mitosis.,similarity:Belongs to the APC8/CDC23 family.,similarity:Contains 9 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,Subcellular Location:
intracellular,nucleoplasm,anaphase-promoting complex,cytosol,Expression:
Bone marrow,Brain,Duodenum,Epithelium,Pancreas,Placenta,
- Western Blot analysis of COS7 cells using Cdc23 Polyclonal Antibody diluted at 1:2000
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