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CD172b Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70732

  • Amount:

    100ul

  • Molecular Weight:

    43255Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human SIRPB1. AA range:231-280

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using CD172b Polyclonal Antibody

  • Gene Name:

    SIRPB1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Signal-regulatory protein beta-1

  • Human Gene Id:

    10326

  • Human Swiss Prot No:

    O00241

  • Specificity:

    CD172b Polyclonal Antibody detects endogenous levels of CD172b protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    SIRPB1; Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD antigen CD172b

  • Observed Band(KD):

    48

  • Background:

    The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],

  • Function:

    function:Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.,function:Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.,PTM:N-glycosylated.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C1-type (immunoglobulin-like) domains.,subunit:Interacts with TYROBP. This interaction results in the recruitment of SYK.,tissue specificity:Detected in monocytes and dendritic cells.,

  • Subcellular Location:

    Cell membrane ; Single-pass type I membrane protein .

  • Expression:

    Detected in monocytes and dendritic cells.

  • Western blot analysis of lysates from HeLa, COLO, and HUVEC cells, using SIRPB1 Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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CD172b Polyclonal Antibody | EnoGene Biotech Co. Ltd