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CBP20 Polyclonal Antibody
Datasheet
Catalog Number:
E20-70696Amount:
100ulMolecular Weight:
18001DaApplications:
WB;IHC-p;IF/ICC;ELISAReactivity:
Human;MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human NCBP2. AA range:10-59Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using CBP20 Polyclonal Antibody
Gene Name:
NCBP2Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.Protein Name:
Nuclear cap-binding protein subunit 2Human Gene Id:
22916Human Swiss Prot No:
P52298Mouse Gene Id:
68092Mouse Swiss Prot No:
Q9CQ49Specificity:
CBP20 Polyclonal Antibody detects endogenous levels of CBP20 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
NCBP2; CBP20; PIG55; Nuclear cap-binding protein subunit 2; 20 kDa nuclear cap-binding protein; Cell proliferation-inducing gene 55 protein; NCBP 20 kDa subunit; CBP20; NCBP-interacting protein 1; NIP1Observed Band(KD):
18Background:
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],Function:
function:Involved in mediating U snRNA export from the nucleus. Binds to 5' capped mRNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RRM NCBP2 family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Found in a U snRNA export complex with RNUXA/PHAX, NCBP1, NCBP2, RAN, XPO1 and m7G-capped RNA (By similarity). Heterodimer with NCBP1. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2.,Subcellular Location:
Nucleus . Cytoplasm .Expression:
Cervix,Cervix carcinoma,Human small intestine,
- Western blot analysis of lysates from COLO205 cells, using NCBP2 Antibody. The lane on the right is blocked with the synthesized peptide.
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