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CBG Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70689

  • Amount:

    100ul

  • Molecular Weight:

    53696Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Rat;Mouse;

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GBA3. AA range:291-340

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using CBG Polyclonal Antibody diluted at 1:500

  • Gene Name:

    GBA3

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Cytosolic beta-glucosidase

  • Human Gene Id:

    57733

  • Human Swiss Prot No:

    Q9H227

  • Specificity:

    CBG Polyclonal Antibody detects endogenous levels of CBG protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GBA3; CBG; CBGL1; Cytosolic beta-glucosidase; Cytosolic beta-glucosidase-like protein 1

  • Observed Band(KD):

    54-58

  • Background:

    The protein encoded by this gene is an enzyme that can hydrolyze several types of glycosides. This gene is a polymorphic pseudogene, with the most common allele being the functional allele that encodes the full-length protein. Some individuals, as represented by the reference genome allele, contain a single nucleotide polymorphism that results in a premature stop codon in the coding region, and therefore this allele is pseudogenic due to the failure to produce a functional full-length protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2013],

  • Function:

    catalytic activity:Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.,enzyme regulation:Inhibited by 2,4-dinitrophenyl-2-fluoro-2-deoxy-beta-D-glucopyranoside and sodium taurocholate.,function:Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens.,PTM:The N-terminus is blocked.,similarity:Belongs to the glycosyl hydrolase 1 family.,similarity:Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.,tissue specificity:Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas.,

  • Subcellular Location:

    Cytoplasm, cytosol .

  • Expression:

    Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas.

  • Western blot analysis of lysates from HUVEC cells, using GBA3 Antibody. The lane on the right is blocked with the synthesized peptide.

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Catalog Number

  • Amount:100ul
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CBG Polyclonal Antibody | EnoGene Biotech Co. Ltd