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Casein Kinase Iα Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-70645

  • Amount:

    100ul

  • Molecular Weight:

    (Da)：38915

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    ：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    ：The antiserum was produced against synthesized peptide derived from human CKI-alpha. AA range:126-175

  • Source:

    ：Polyclonal, Rabbit,IgG

  • Immunofluorescence analysis of HeLa cells, using CKI-alpha Antibody. The picture on the right is blocked with the synthesized peptide.

  • Gene Name:

    ：CSNK1A1

  • Dilution:

    ：Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    ：Casein kinase I isoform alpha

  • Human Gene Id:

    ：1452

  • Human Swiss Prot No:

    ：P48729

  • Mouse Swiss Prot No:

    ：Q8BK63

  • Rat Gene Id:

    ：113927

  • Rat Swiss Prot No:

    ：P97633

  • Specificity:

    ：Casein Kinase Iα Polyclonal Antibody detects endogenous levels of Casein Kinase Iα protein.

  • Formulation:

    ：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    ：1 mg/ml

  • Storage Stability:

    ：-20°C/1 year

  • Other Name:

    ：CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1

  • Observed Band(KD):

    ：35

  • Background:

    ：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex.,

  • Function:

    ：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex.,

  • Subcellular Location:

    ：Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, spindle . Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). .

  • Expression:

    ：Brain,Epithelium,Liver,Lung,Placenta,Skin,

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Catalog Number

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Casein Kinase Iα Polyclonal Antibody | EnoGene Biotech Co. Ltd