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Cell Signal Transduction Research Antibodies
Calpain 10 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight74938Da
Protein NameCalpain-10
Human Gene Id11132
Human Swiss Prot NoQ9HC96
Mouse Swiss Prot NoQ9ESK3
SpecificityCalpain 10 Polyclonal Antibody detects endogenous levels of Calpain 10 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCAPN10; KIAA1845; Calpain-10; Calcium-activated neutral proteinase 10; CANP 10
Observed Band(KD)75
Functioncatalytic activity:Broad endopeptidase specificity.,disease:Genetic variations in CAPN10 are associated with susceptibility to non-insulin-dependent diabetes mellitus type 1 (NIDDM1) [MIM:601283]. Diabetes mellitus is a heterogeneous group of metabolic diseases characterized by high blood glucose levels which, if untreated, lead to blindness, kidney and heart disease, stroke, loss of limbs and reduced life expectancy. Diabetes mellitus can be divided into two main types, type 1 or insulin-dependent diabetes mellitus, and type 2 or non insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. NIDDM normally starts in adulthood and is characterized by defects in insulin action and insulin secretion.,function:Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,similarity:Belongs to the p
Subcellular Locationintracellular,cell,mitochondrion,cytosol,plasma membrane,
ExpressionBrain,Skin,Uterus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the N-terminal region of human Calpain 10.
Gene NameCAPN10
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Backgroundcalpain 10(CAPN10) Homo sapiens Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq,
Conjugated Antibody
This product is also available conjugated. Format: E20-70614-Conjugate. Price: $485 / Size: 100μl.
E20-70614-FITC$485 / 100μlE20-70614-Biotin$485 / 100μlE20-70614-HRP$485 / 100μlE20-70614-AP$485 / 100μlE20-70614-AF350$485 / 100μlE20-70614-AF405M$485 / 100μlE20-70614-AF488$485 / 100μlE20-70614-AF514$485 / 100μlE20-70614-AF532$485 / 100μlE20-70614-AF555$485 / 100μlE20-70614-AF568$485 / 100μlE20-70614-AF405S$485 / 100μlE20-70614-AF405L$485 / 100μlE20-70614-AF546$485 / 100μlE20-70614-AF594$485 / 100μlE20-70614-AF610$485 / 100μlE20-70614-AF635$485 / 100μlE20-70614-AF647$485 / 100μlE20-70614-AF680$485 / 100μlE20-70614-AF700$485 / 100μlE20-70614-AF750$485 / 100μlE20-70614-AF790$485 / 100μlE20-70614-APC$485 / 100μlE20-70614-PE$485 / 100μlE20-70614-Cy3$485 / 100μlE20-70614-Cy5$485 / 100μlE20-70614-Cy5.5$485 / 100μlE20-70614-Cy7$485 / 100μlE20-70614-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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